Polypeptides maintain the structure of the dermo-epidermal junction, the area of tissue that joins the epidermis with dermal layers of skin, needed for skin cohesion and providing essential nutrients to the epidermis. By stimulating the synthesis of major essential proteins and collagen in the dermo-epidermal junction (DEJ), skin integrity is maintained, and cells can repair effectively. Skin appears firmer, suppler and more youthful.